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Week 16 NFL Picks Against the Spread

The NFL has taken over Christmas weekend, and is giving us a potential Super Bowl preview with Ravens-49ers on Monday night. Here are the picks for every game on the Week 16 slate.

Getty Images/Ringer illustration

Editor’s Note: Sheil is out sick this week, so this picks column looks a little different as we head into Week 16 and a full slate of games over the Christmas holiday weekend. Sheil went ahead and picked each game against the spread, so if you’ve been using his picks as a guide this season (if you have stuck with him this far, thank you for your trust and loyalty, but are you sure you’re OK?) we’ve got you covered. If he’s feeling better before the Sunday games kick off, this post may be updated with the matchup breakdowns and advanced analytics and self-deprecating humor you’re used to.

Now, on to the picks! Lines are from FanDuel as of Thursday afternoon.


Last week: 5-10-1

Season: 106-110-8

New Orleans Saints at Los Angeles Rams (-3.5)

The pick: Rams (-3.5)

Cincinnati Bengals at Pittsburgh Steelers (+1.5)

The pick: Steelers (+1.5)

Buffalo Bills at Los Angeles Chargers (+12.5)

The pick: Bills (-12.5)

Indianapolis Colts at Atlanta Falcons (+1.5)

The pick: Falcons (-1.5)

Green Bay Packers at Carolina Panthers (+4.5)

The pick: Packers (-4.5)

Cleveland Browns at Houston Texans (-2.5)

The pick: Browns (-2.5)

Detroit Lions at Minnesota Vikings (+3)

The pick: Lions (-3)

Washington Commanders at New York Jets (-3)

The pick: Commanders (+3)

Seattle Seahawks at Tennessee Titans (+2.5)

The pick: Titans (+2.5)

Jacksonville Jaguars at Tampa Bay Buccaneers (-1.5)

The pick: Jaguars (+1.5)

Arizona Cardinals at Chicago Bears (-4.5)

The pick: Cardinals (+4.5)

Dallas Cowboys at Miami Dolphins (-1.5)

The pick: Cowboys (+1.5)

New England Patriots at Denver Broncos (-6.5)

The pick: Patriots (+6.5)

Las Vegas Raiders at Kansas City Chiefs (-10)

The pick: Raiders (+10)

New York Giants at Philadelphia Eagles (-11.5)

The pick: Eagles (-11.5)

Baltimore Ravens at San Francisco 49ers (-5.5)

The pick: Ravens (+5.5)